| 别名 | Platelet endothelial cell adhesion molecule;PECAM-1;CD31;Pecam1;Pecam |
| 英文名称 | Recombinant Mouse CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule |
| 中文名称 | 重组小鼠CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | 冷藏运输 |
| 背景说明 | Platelet endothelial cell adhesion molecule (PECAM-1，CD31) is a type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily.PECAM-1 is concentrated at cell junctions and is required for transendothelial migration (TEM).The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains，the first of which is critical for adhesion and extravasation.The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM，ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules.Expression is restricted to cells involved in circulation，especially endothelial cells，platelets，monocytes，neutrophils and lymphocyte subsets.PECAM-1 participates with other adhesion molecules in some functions，but is the critical molecule for TEM.Homotypic PECAM-1 adhesion in trans，combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles，leads leukocytes across endothelial tight junctions. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
