| 英文名称 | Anti-IDE Polyclonal Antibody |
| 中文名称 | 胰岛素降解酶抗体 |
| 规格 | 100ul ; 50ul |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human ; Rat ; Mouse |
| 应用 | WB ; IHC-P |
| 稀释比例 | WB 1:500-2000. IHC-P 1:10-50. |
| 靶标 | IDE |
| 别名 | BC2, Insulin degrading enzyme, FLJ35968, insulin protease, insulinase, insulysin, Abeta-degrading protease, FLJ35968, Ide, IDE_HUMAN, Insulin-degrading enzyme, |
| 背景说明 | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |
| Swiss Prot | P14735 |
| Gene ID | 3416 |
| 亚细胞定位 | Cell membrane Cytoplasm Secreted |
| 研究领域 | 神经学 ; 新陈代谢 |
| 免疫原 | Recombinant protein of human IDE |
| Public Immunogen Range | 700-1019aa |
| 理论分子量 | 118kDa |
| 纯化方法 | Affinity purification |
| 储存液 | pH7.4 PBS，0.05% NaN3，40% Glycerol. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
| 运输条件 | 冷冻运输 |
| 单位 | 支 |
| 属性分类 | 其他抗体 |
