| 别名 | ECA4,EIEE19,EJM,EJM5,Gaba receptor alpha 1 polypeptide,GABA(A) receptor,GABA(A) receptor subunit alpha 1,GABA(A) receptor subunit alpha-1,GABA(A) receptor,alpha 1,GABRA 1,GABRA1,Gamma aminobutyric acid (GABA) A receptor alpha 1,Gamma aminobutyric acid A receptor alpha 1,Gamma aminobutyric acid receptor subunit alpha 1,Gamma aminobutyric acid type A receptor alpha1 subunit,Gamma-aminobutyric acid receptor subunit alpha-1,GBRA1_HUMAN |
| 背景说明 | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). |
