产品货号:jlcR20189 英文名称:MCU 中文名称:线粒体钙离子单向转运蛋白MCU抗体 别名:MCU_HUMAN; C10orf42; Ccdc109a; Coiled-coil domain-containing protein 109A; Mitochondrial Calcium Uniporter. 研究领域:心血管细胞生物转运蛋白 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, h 产品应用:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量:40kDa 细胞定位:细胞膜 性状:Lyophilized or Liquid 浓度:1mg/ml 免疫原:KLH conjugated synthetic peptide derived from human MCU:251-351//351 亚型:IgG 纯化方法:affinity purified by Protein A 储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍background: This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.
Subunit: Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Heterotetramer with CCDC109B/MCUB; this inhibits channel activity. Homotetramer. Interacts with MICU1; MICU1 acts as an essential regulator for MCU. Interacts with MCUR1; interaction with MICU1 and MCUR1 are mutually exclusive.
Subcellular Location: Membrane.
Similarity: Belongs to the CCDC109 family.
SWISS: Q8NE86
Gene ID: 90550
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
