FITC标记的B淋巴细胞成熟因子抗体

¥2980
LMAI Bio
中国/美国/欧洲
2021-06-16 23:16

上海联迈生物工程有限公司

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产品属性
供应商上海联迈生物工程有限公司
数量大量
靶点详见说明书
级别1
目录编号LM-3850R-FITC
克隆性多克隆
抗原来源Rabbit
保质期1年
抗体英文名Anti-BCMA/FITC
抗体名Anti-BCMA/FITC
标记物FITC标记
宿主Human, Mouse, Rat,
适应物种Human, Mouse, Rat,
免疫原详见说明书
亚型IGg
形态粉末、液体、冻干粉
应用范围Flow-Cyt=1:50-200 IF=1:50-200
浓度1mg/ml
保存条件-20 °C
规格100ul
产品说明
FITC标记的B淋巴细胞成熟因子抗体
英文名称Anti-BCMA/FITC
中文名称FITC标记的B淋巴细胞成熟因子抗体
别 名B cell maturation antigen; B Cell Maturation Factor; B cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; Tumor Necrosis Factor Receptor Member 17; Tumor necrosis factor receptor superfamily member 17; TNR17_HUMAN.
规格价格100ul/2980元 购买 大包装/询价
说 明 书100ul
研究领域肿瘤 细胞生物 免疫学 转录调节因子 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
产品应用Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BCMA
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq].

Function:
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Subunit:
Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

Subcellular Location:
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein.

Tissue Specificity:
Expressed in mature B-cells, but not in T-cells or monocytes. 

DISEASE:
Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Similarity:
Contains 1 TNFR-Cys repeat.

Database links:

Entrez Gene: 608 Human

Omim: 109545 Human

SwissProt: Q02223 Human

Unigene: 2556 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.