A facile method for the synthesis of dihydroquinoline-azide from the Lewis acid-catalyzed reaction of alkylidenecyclopropanes with TMSN3†
Mintao Chen,Yin Wei,Min Shi
Organic & Biomolecular Chemistry Pub Date : 11/12/2019 00:00:00 , DOI:10.1039/C9OB02309G
Abstract

A facile synthetic method for the formation of dihydroquinoline-azide from alkylidenecyclopropanes and TMSN3 under the catalysis of a Lewis acid has been developed, and a number of azide-containing compounds can be instantly accessed in moderate to good yields. A click reaction with these azido compounds was also realized along with a mechanistic investigation.

Graphical abstract: A facile method for the synthesis of dihydroquinoline-azide from the Lewis acid-catalyzed reaction of alkylidenecyclopropanes with TMSN3