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A facile approach to highly functional trisubstituted furansvia intramolecular Wittig reactions†
Ko-Wei Chen,Siang-en Syu,Yeong-Jiunn Jang,Wenwei Lin
Organic & Biomolecular Chemistry Pub Date : 12/17/2010 00:00:00 , DOI:10.1039/C0OB00912A
Abstract

An efficient and mild synthesis of trisubstituted furans, starting from α,β-unsaturated ketones, tributylphosphine, and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to install the crucial furan ring, leading to a wide variety of highly functional furans in one step.

Graphical abstract: A facile approach to highly functional trisubstituted furansvia intramolecular Wittig reactions
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