Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions†,10.1039/C4OB02538E

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions†

Fabio Doro,Cinzia Colombo,Chiara Alberti,Daniela Arosio,Cesare Casagrande,Roberto Fanelli,Leonardo Manzoni,Emilio Parisini,Umberto Piarulli,Elena Luison,Mariangela Figini,Antonella Tomassetti,Monica Civera

Organic & Biomolecular Chemistry Pub Date : 01/14/2015 00:00:00 , DOI:10.1039/C4OB02538E

Abstract

We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.