Combining sugar biosynthesis genes for the generation of l- and d-amicetose and formation of two novel antitumor tetracenomycins†
María Pérez,Felipe Lombó,Lili Zhu,Miranda Gibson,Alfredo F. Braña,Jürgen Rohr,José A. Salas,Carmen Méndez
Abstract
L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.
