Concise syntheses of bridged morpholines†
Andrey V. Zaytsev,James E. Pickles,Suzannah J. Harnor,Alistair P. Henderson,Mohammed Alyasiri,Paul G. Waddell,Celine Cano,Roger J. Griffin
RSC Advances Pub Date : 05/27/2016 00:00:00 , DOI:10.1039/C6RA08737J
Abstract

Concise and practical syntheses of 8-oxa-3-aza-bicyclo[3.2.1]octane and 9-oxa-3-aza-bicyclo[3.3.1]nonane are described starting from furan-2,5-dicarboxylic acid and 4H-pyran-2,6-dicarboxylic acid, respectively, and using a solvent-free step for a key cyclisation.

Graphical abstract: Concise syntheses of bridged morpholines
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