Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor†
Luigi Margarucci,Maria Chiara Monti,Chiara Cassiano,Matteo Mozzicafreddo,Mauro Angeletti,Raffaele Riccio,Alessandra Tosco,Agostino Casapullo
Chemical Communications Pub Date : 05/09/2013 00:00:00 , DOI:10.1039/C3CC41858H
Abstract
Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.
