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A general and practical route to 4,5-disubstituted oxazoles using acid chlorides and isocyanides†
Dipak Kumar Tiwari,Jaya Pogula,Dharmendra Kumar Tiwari
RSC Advances Pub Date : 06/04/2015 00:00:00 , DOI:10.1039/C5RA07668D
Abstract

An efficient and mild method for the synthesis of 4,5-disubstituted oxazoles has been developed. A series of 4,5-disubstituted oxazoles were prepared via [3 + 2] cycloaddition reaction of various isocyanides and acid chlorides in the presence of base. This method serves as an efficient preparation of 5-formyloxazole which might prove to be a synthetically useful intermediate.

Graphical abstract: A general and practical route to 4,5-disubstituted oxazoles using acid chlorides and isocyanides
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