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Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions†
Surabhi Gupta,Priyanka Chaudhary,Nalluchamy Muniyappan,Shahulhameed Sabiah,Jeyakumar Kandasamy
Organic & Biomolecular Chemistry Pub Date : 09/20/2017 00:00:00 , DOI:10.1039/C7OB02234D
Abstract

The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive L-methionine sulfoximine derivative was demonstrated under standard reaction conditions.

Graphical abstract: Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions
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