960化工网
Convenient synthesis of substituted tetrahydrofuran via Lewis base catalyzed [3 + 2] domino reactions†
Yufen Liu,Qi Zhang,Yanlong Du,Aimin Yu,Kui Zhang,Xiangtai Meng
RSC Advances Pub Date : 10/07/2014 00:00:00 , DOI:10.1039/C4RA09249J
Abstract

A DABCO catalyzed domino reaction between 3-oxo-4-(2-oxoindolin-3-ylidene) butanoates and allenoates furnished 2,3,5-substituted tetrahydrofuran furan derivatives with oxindole moieties and two exocyclic double bonds in high yield. During this reaction, two carbon atoms and one oxygen atom of 3-oxo-4-(2-oxoindolin-3-ylidene) butanoates participated. Moreover, four isomers were synthesized and two of them can be isolated in this reaction.

Graphical abstract: Convenient synthesis of substituted tetrahydrofuran via Lewis base catalyzed [3 + 2] domino reactions
平台客服
平台客服
平台在线客服