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Convergent routes to substituted naphthylamides†‡
Ngoc Diem My Tran,Samir Z. Zard
Organic & Biomolecular Chemistry Pub Date : 03/13/2014 00:00:00 , DOI:10.1039/C4OB00339J
Abstract

Practical, convergent routes to variously substituted 1- and 2-naphthylamides have been developed. They exploit the ability of xanthates to undergo both intermolecular radical additions to vinyl pivalate and intramolecular radical cyclisations to aromatic rings. In the case of 1-naphthylamides, the existence of an intramolecular hydrogen bond was used to facilitate the cyclisation step.

Graphical abstract: Convergent routes to substituted naphthylamides
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