Construction of medium-ring oxacycloalkenones. Extension towards benzo-fused cyclic ethers
Frédéric Lecornué,Jean Ollivier
Organic & Biomolecular Chemistry Pub Date : 09/23/2003 00:00:00 , DOI:10.1039/B307289B
Abstract

Application of the intramolecular Kulinkovich cyclopropanation of oxa-ω-alkenoic esters followed by Saegusa oxidation and dehydrohalogenation led to simple or benzo-fused oxacycloalkenones, basic structural elements in a wide range of naturally occurring compounds.

Graphical abstract: Construction of medium-ring oxacycloalkenones. Extension towards benzo-fused cyclic ethers