“O-Acyl isopeptide method” for peptide synthesis: synthesis of forty kinds of “O-acyl isodipeptide unit” Boc-Ser/Thr(Fmoc-Xaa)-OH†
Taku Yoshiya,Atsuhiko Taniguchi,Fukue Fukao,Setsuko Nakamura,Naoko Abe,Nui Ito,Mariusz Skwarczynski,Tooru Kimura,Yoshio Hayashi,Yoshiaki Kiso
Organic & Biomolecular Chemistry Pub Date : 04/25/2007 00:00:00 , DOI:
10.1039/B702284KAbstract
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of “O-acyl isodipeptide unit” Boc-Ser/Thr(Fmoc-Xaa)-OH (1–40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.
