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“On water” sp3–sp2 cross-couplings between benzylic and alkenyl halides†
Valeria Krasovskaya,Arkady Krasovskiy,Anish Bhattacharjya,Bruce H. Lipshutz
Chemical Communications Pub Date : 04/12/2011 00:00:00 , DOI:10.1039/C1CC11087J
Abstract

Organic-solvent-free cross-couplings between benzylic and alkenyl halides have been developed. Various alkenyl halides can be efficiently benzylated by combining the precursor halides in the presence of Zn dust and a Pd catalyst at room temperature, in water as the only medium.

Graphical abstract: “On water” sp3–sp2 cross-couplings between benzylic and alkenyl halides
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