A three-component domino reaction of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and a pyridinium salt in the presence of ammonium acetate, under microwave irradiation and using water as solvent, furnished a library of novel 2-arylcarbonyl-3-aryl-4,9-dihydronaphtho[2,3-b]furan-4,9-diones in good yields, in a transformation that presumably proceeds via an α,β-unsaturated triketone generation/Michael addition/intramolecular cyclisation/air oxidation one-pot sequence.