A facile aminocyclization for the synthesis of pyrrolidine and piperidine derivatives†
Jingbo Chen,Yongqiang Tu,Liang Li,Hongbin Zhang
Chemical Communications Pub Date : 06/26/2003 00:00:00 , DOI:10.1039/B304157C
Abstract

Bromination of an isolated double bond followed by aminocyclization furnishes a highly stereoselective protocol for the intramolecular formation of pyrrolidine and piperidine ring containing subunits that are presented in numerous biologically active natural products.

Graphical abstract: A facile aminocyclization for the synthesis of pyrrolidine and piperidine derivatives