Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum†,10.1039/B510812H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum†

Arin Ghasparian,Kerstin Moehle,Anthony Linden,John A. Robinson

Chemical Communications Pub Date : 11/21/2005 00:00:00 , DOI:10.1039/B510812H

Abstract

A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH₂, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I β-turn, which is stabilized by hydrogen bonding between the CO of Asn² and the NH of Ala⁵ as well as between the O(δ) of Asn² and the NH of Asn⁴.