Convergent synthesis and preliminary biological evaluations of the stilbenolignan (±)-aiphanol and various congeners
Martin G. Banwell,Anna Bezos,Satish Chand,Gerd Dannhardt,Werner Kiefer,Ulrike Nowe,Christopher R. Parish,G. Paul Savage,Holger Ulbrich
Organic & Biomolecular Chemistry Pub Date : 06/23/2003 00:00:00 , DOI:
10.1039/B305106DAbstract
Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone–benzene afforded a ca. 2 : 1 : 2 : 1 mixture of the stilbenolignan (±)-aiphanol (1) and congeners 2–4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.
