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Control of diastereoselectivity in the crotylation and cinnamylation of aldehydes by the selection of ligands on allylic indium reagents
Tsunehisa Hirashita,Toshiya Kamei,Makoto Satake,Tomoaki Horie,Hidetaka Shimizu,Shuki Araki
Organic & Biomolecular Chemistry Pub Date : 10/03/2003 00:00:00 , DOI:10.1039/B306195G
Abstract

Diastereoselective couplings of salicylaldehyde, anisaldehyde and 2-pyridylaldehyde with crotyl- and cinnamyl-indium reagents were studied. The syn/anti selectivity was found to depend largely on the ligands on the indium atom of the allylic indium reagents. A syn-selective cinnamylation of salicylaldehyde was realized by the combination of cinnamyl acetate and indium(I) iodide, whereas an anti-selective coupling with salicylaldehyde was achieved by the indium trichloride/aluminium-mediated cinnamylation.

Graphical abstract: Control of diastereoselectivity in the crotylation and cinnamylation of aldehydes by the selection of ligands on allylic indium reagents
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