Cu-catalyzed aerobic oxidative C–CN bond cleavage of benzyl cyanide for the synthesis of primary amides†,10.1039/C7RA02207G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Cu-catalyzed aerobic oxidative C–CN bond cleavage of benzyl cyanide for the synthesis of primary amides†

Xiuling Chen,Yanhong Peng,Yan Li,Minghu Wu,Haibing Guo,Jian Wang,Shaofa Sun

RSC Advances Pub Date : 03/28/2017 00:00:00 , DOI:10.1039/C7RA02207G

Abstract

An efficient method via copper-catalyzed aerobic oxidative amidation of benzyl cyanide for primary amides is successfully developed. Using readily available NH₄Cl as a nitrogen source and Cu/O₂ as a catalytic oxidation system offers new opportunities for C–CN bond cleavage and primary amide bond formation.