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Copper-catalyzed reductive amination of aromatic and aliphatic ketones with anilines using environmental-friendly molecular hydrogen†
Svenja Werkmeister,Kathrin Junge,Matthias Beller
Green Chemistry Pub Date : 06/14/2012 00:00:00 , DOI:10.1039/C2GC35565E
Abstract

A convenient and practical copper-catalyzed reductive amination was discovered. In the presence of easily available and inexpensive Cu(OAc)2 various ketones react with anilines and molecular hydrogen to give the desired amines in high yields.

Graphical abstract: Copper-catalyzed reductive amination of aromatic and aliphatic ketones with anilines using environmental-friendly molecular hydrogen
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