Copper-promoted cascade reaction of active methylenes with MBH-acetates of acetylenic aldehydes to functionalized cyclopentenes†,10.1039/C3RA46229C

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Copper-promoted cascade reaction of active methylenes with MBH-acetates of acetylenic aldehydes to functionalized cyclopentenes†

Chada Raji Reddy,Paridala Kumaraswamy

RSC Advances Pub Date : 11/19/2013 00:00:00 , DOI:10.1039/C3RA46229C

Abstract

One-pot synthesis of substituted cyclopentenes was accomplished through a copper-mediated [4 + 1]-annulation of active methylene compounds with Morita–Baylis–Hillman (MBH) acetates of acetylenic aldehydes. The reaction sequence involves the cascade allylic substitution/5-exo-dig-carbocyclization, which was effective in providing methylene, alkylidene as well as arylidene cyclopentenes.