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Chirality transfer during alkylation of chiral amides
Takeo Kawabata,Orhan Öztürk,Jianyong Chen,Kaoru Fuji
Chemical Communications Pub Date : 12/06/2002 00:00:00 , DOI:10.1039/B209736B
Abstract

Chiral amides derived from O-methyl mandelic acid and achiral amines underwent enantioselective α-methylation on treatment with LTMP followed by addition of methyl iodide; chirality transfer from an undeprotonated chiral amide into an achiral enolate in a mixed aggregate is supposed to be responsible for the asymmetric induction.

Graphical abstract: Chirality transfer during alkylation of chiral amides
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