A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes†
Cristina Chamorro,John A. W. Kruijtzer,Marina Farsaraki,Jan Balzarini,Rob M. J. Liskamp
Chemical Communications Pub Date : 12/17/2008 00:00:00 , DOI:10.1039/B817357E
Abstract
In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.
