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A general Pd/Cu-catalyzed C–H heteroarylation of 3-bromoquinolin-2(1H)-ones†
Alexandre Bruneau,Jean-Daniel Brion,Samir Messaoudi,Mouad Alami
Organic & Biomolecular Chemistry Pub Date : 09/01/2014 00:00:00 , DOI:10.1039/C4OB01610F
Abstract

3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C–H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.

Graphical abstract: A general Pd/Cu-catalyzed C–H heteroarylation of 3-bromoquinolin-2(1H)-ones
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