A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines
Vito Fiandanese,Silvia Maurantonio,Angela Punzi,Giacomo G. Rafaschieri
Organic & Biomolecular Chemistry Pub Date : 11/17/2011 00:00:00 , DOI:10.1039/C1OB06701J
Abstract

A general procedure for the synthesis of the title compounds has been devised starting from the available 2-halophenylethyl azides, by means of click reactions with trimethylsilylacetylene or 1-trimethylsilyl-1,3-butadiyne followed by a transition metal-catalyzed functionalization of C–H bond. A further extension of this procedure led us to devise the synthesis of more complex 4,4′-bitriazole-fused dihydroisoquinolines.

Graphical abstract: A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines