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CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases†
Manda Bhaskar Reddy,Potuganti Gal Reddy,Myadaraboina Shailaja,Alla Manjula,Tadikamalla Prabhakar Rao
RSC Advances Pub Date : 10/10/2016 00:00:00 , DOI:10.1039/C6RA21437A
Abstract

A convenient method for the amination of Tröger's base halides has been developed via copper catalyzed coupling reactions. This reaction proceeds in moderate to good yields. The protocol has been utilized to produce two different classes of Tröger's base derivatives, one bearing identical substituents on both the aryl rings and the other featuring two different substituents on the aryl rings.

Graphical abstract: CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases
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