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Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations†
Max J. Cryle,Julia M. U. Stuthe,Paul R. Ortiz de Montellano,James J. De Voss
Chemical Communications Pub Date : 01/27/2004 00:00:00 , DOI:10.1039/B315911F
Abstract

Novel cyclopropyl containing fatty acids are good substrates for P450BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 × 1010 s−1) and the absence of any cationic intermediate.

Graphical abstract: Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations
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