Diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones through metal-free cyclopropanation using tosylhydrazone salts†,10.1039/C4RA05755D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones through metal-free cyclopropanation using tosylhydrazone salts†

Chada Narsimha Reddy,Praveen Reddy Adiyala,Ranjita Nayak,V. Lakshma Nayak,Jagadeesh Babu Nanubolu,Kiran Kumar Singarapu,Ram Awatar Maurya

RSC Advances Pub Date : 08/13/2014 00:00:00 , DOI:10.1039/C4RA05755D

Abstract

Transition metal-free diastereoselective cyclopropanation of 3-methyleneindolin-2-ones using tosylhydrazone salts as a safe alternative to diazo-compounds was achieved in high yields. All the synthesized compounds were evaluated for their biological activity against three different human cancer cell lines DU-145 (prostate cancer), Hela (cervical cancer) and A-549 (lung cancer). Compounds 3b and 3i exhibited promising anticancer activity (IC₅₀ < 10 μM) against the studied cell lines.