Divergent synthetic approach to 6′′-modified α-GalCer analogues†,10.1039/C1OB06235B

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Divergent synthetic approach to 6′′-modified α-GalCer analogues†

Nora Pauwels,Sandrine Aspeslagh,Gerd Vanhoenacker,Koen Sandra,Esther D. Yu,Dirk M. Zajonc,Dirk Elewaut,Bruno Linclau,Serge Van Calenbergh

Organic & Biomolecular Chemistry Pub Date : 09/02/2011 00:00:00 , DOI:10.1039/C1OB06235B

Abstract

A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6′′-modified KRN7000 analogues.