Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs†
Hirokazu Tamamura,Hiroshi Tsutsumi,Hiroyuki Masuno,Satoko Mizokami,Kenichi Hiramatsu,Zixuan Wang,John O. Trent,Hideki Nakashima,Stephen C. Peiper,Nobutaka Fujii
Organic & Biomolecular Chemistry Pub Date : 05/12/2006 00:00:00 , DOI:
10.1039/B603818BAbstract
A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.
