Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins†,10.1039/C4OB00622D

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins†

Jun Yamamoto,Masaya Denda,Nami Maeda,Miku Kita,Chiaki Komiya,Tomohiro Tanaka,Wataru Nomura,Hirokazu Tamamura,Youichi Sato,Aiko Yamauchi,Akira Otaka

Organic & Biomolecular Chemistry Pub Date : 04/17/2014 00:00:00 , DOI:10.1039/C4OB00622D

Abstract

A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of the target protein but also selective labelling to pick out the target from contaminated non-target proteins for facile identification.