Valinamide carbamates are important agricultural fungicides with anti-oomycete activity and low toxicity toward mammalian cells. To find valinamide carbamates with high activity against resistant pathogens, a series of substituted 1-phenyl-2-phenoxyethylamino derivatives were designed and synthesized by introducing substituted phenyloxy or benzyloxy into valinamide carbamate leads. Bioassays showed that many title compounds exhibited good anti-oomycete activity. Compound 8b had much higher in vitro fungicidal activity against Phytophthora capsici than the control compound iprovalicarb and had a similar potency to the control mandipropamid. At 6.25 μg mL⁻¹ the fungicidal activities of many compounds against in vivo Pseudoperonospora cubensis were greater than 30%, while the control dimethomorph gave only 27% activity at this concentration. The effect of 8b against Pseudoperonospora cubensis in the field indicates promise for a new candidate for controlling cucumber downy mildew.