960化工网
Diastereoselective three-component reactions of aryldiazoacetates with alcohols/water and alkynals: application to substituted enelactones†
Liqing Jiang,Min Tang,Wenhao Hu
Organic & Biomolecular Chemistry Pub Date : 03/02/2011 00:00:00 , DOI:10.1039/C1OB05076A
Abstract

Dirhodium acetate catalyzed three-component reactions of aryl diazoacetates, alcohols or water, and 2-alkynals are reported to afford β-alkynyl α,β-dihydroxyl acid esters in good yield with high diastereoselectivity. Synthetic utility of the reaction was demonstrated in the conversion of the versatile alkynyl functionality to other synthetically useful compounds, including efficient synthesis of 2-aryl-2,3-dihydroxyl enelactones.

Graphical abstract: Diastereoselective three-component reactions of aryldiazoacetates with alcohols/water and alkynals: application to substituted enelactones
平台客服
平台客服
平台在线客服