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A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)†
Wei Chen,Yicheng Zhang,Lei Zhang,Min Wang
Chemical Communications Pub Date : 08/22/2011 00:00:00 , DOI:10.1039/C1CC13967C
Abstract

A highly efficient tetra-(n-butyl)ammonium fluoride (TBAF)-promoted intramolecular cyclization of gem-dibromoolefins has been developed for the synthesis of 2-bromobenzofused heterocycles. The reaction provides a convenient approach to 2-bromobenzofurans(thiophenes) from the corresponding readily available gem-dibromovinyl substrates without a metal.

Graphical abstract: A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)
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