Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles†,10.1039/C6CC02776H

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Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles†

Ming Chen,Ning Sun,Haoyi Chen,Yuanhong Liu

Chemical Communications Pub Date : 04/04/2016 00:00:00 , DOI:10.1039/C6CC02776H

Abstract

A gold-catalyzed regioselective [3+2] cycloaddition of ynamides with 1,4,2-dioxazoles was developed and offers a novel approach to obtain highly functionalized oxazoles under mild reaction conditions. 1,4,2-Dioxazole was found to act as an efficient N-acyl nitrene equivalent to trigger a facile generation of α-imino gold–carbene intermediate through the elimination of a ketone.