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Direct O-glycosidation of resin bound thioglycosides†
Son Hong Nguyen,Adam H. Trotta,John Cao,Timothy J. Straub,Clay S. Bennett
Organic & Biomolecular Chemistry Pub Date : 12/20/2011 00:00:00 , DOI:10.1039/C2OB06883D
Abstract

The application of the safety-catch linker concept to solid-phase glycoconjugate synthesis is described. The process allows for direct conjugation of resin bound glycans to complex aglycones during cleavage. Large excesses of either coupling partner are not required, and even very hindered alcohols serve as acceptors in the reaction.

Graphical abstract: Direct O-glycosidation of resin bound thioglycosides
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