Copper(ii)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling†,10.1039/C7RA01983A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Copper(ii)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling†

Congjun Xu,Mingze Qin,Jun Yi,Yanjing Wang,Yanfeng Chen,Bingfu Zhang,Yanfang Zhao,Ping Gong

RSC Advances Pub Date : 05/05/2017 00:00:00 , DOI:10.1039/C7RA01983A

Abstract

A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was implemented via an oxygen mediated radical mechanism. Potassium ferricyanide played a dual role as a “CN” source and also as a coupling partner for the cyclization of oxazole.