A copper-mediated oxidative isoperfluoropropylation of unactivated terminal alkenes with commercially available hexafluoropropylene (HFP) has been developed. With operational simplicity of the procedure and broad substrate applicability, this strategy provides a general and straightforward way for the construction of C(sp3)–C3F7-i bonds. A variety of allylic isoperfluoropropylated compounds have been efficiently synthesized using this strategy.
