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Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated estersvia a product-base mechanism†‡
Yasuhiro Yamashita,Hirotsugu Suzuki,Shū Kobayashi
Organic & Biomolecular Chemistry Pub Date : 04/03/2012 00:00:00 , DOI:10.1039/C2OB25522G
Abstract

A catalytic Mannich reaction of a simple ester with no activating functionality at the α-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Brønsted base-catalyzed Mannich reaction of unactivated esters as substrates.

Graphical abstract: Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism
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