Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile†‡,10.1039/C2CC31230A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile†‡

Yujiro Hayashi,Yusuke Yasui,Masahiro Kojima,Tsuyoshi Kawamura,Hayato Ishikawa

Chemical Communications Pub Date : 03/30/2012 00:00:00 , DOI:10.1039/C2CC31230A

Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.