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Divergent reaction: metal & oxidant free direct C–H aryloxylation and hydride free formal reductive N-benzylation of N-heterocycles†
Sujit Mahato,Md Ashraful Haque,Soumita Dwari,Chandan K. Jana
RSC Advances Pub Date : 09/15/2014 00:00:00 , DOI:10.1039/C4RA05045B
Abstract

Metal, oxidant and other additive-free novel methods for direct C–H aryloxylation of aliphatic amines are developed. In the presence of excess amine, the course of the reaction was diverted, producing various arylmethylamines via hydride-free formal reductive amination. Involvement of a quinone methide intermediate was revealed from mechanistic studies.

Graphical abstract: Divergent reaction: metal & oxidant free direct C–H aryloxylation and hydride free formal reductive N-benzylation of N-heterocycles
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