This paper reviews a vast body of literature on diverse synthetic methodologies, biological, and fluorescence activities of pyrrolo/indolo[3,2-c]coumarin derivatives published during last 20 years. Synthesized pyrrolo/indolo[3,2-c]coumarins have been reported in the literature by the construction of either pyrrole, indole, or coumarin ring via classical reaction protocols including metal-catalyzed reactions, and green reaction protocols starting from suitable precursors.