A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors†
Anatolie Dobrov,Simone Göschl,Michael A. Jakupec,Ana Popović-Bijelić,Astrid Gräslund,Peter Rapta,Vladimir B. Arion
Abstract
A new paullone–TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.
