960化工网
Direct C2-arylation of N-acyl pyrroles with aryl halides under palladium catalysis†
Weiqiang Chen,Yun-Fei Cheng,Yan-Chao Wu
Organic & Biomolecular Chemistry Pub Date : 01/21/2021 00:00:00 , DOI:10.1039/D0OB02579H
Abstract

C2-arylation of N-acyl pyrroles with aryl halides is developed for the first time using Pd(PPh3)4 as a catalyst in combination with Ag2CO3 under air, which allowed the application of a good compatibility catalytic system. This protocol provides a straightforward method for the preparation of valuable arylated pyrroles in moderate to good yields under the standard conditions with good substrate tolerance. Interestingly, while N-benzoyl pyrroles reacted well, the use of substrates with a thiophene or furan ring indicated that the thiophene and furan rings are more reactive than pyrrole for the present catalytic system.

Graphical abstract: Direct C2-arylation of N-acyl pyrroles with aryl halides under palladium catalysis
平台客服
平台客服
平台在线客服