A novel electrochemical sensor was fabricated for the determination of bisphenol A (BPA) based on a signal amplification strategy with polyacrylamide and multiwalled carbon nanotubes (PAM–MWCNTs). The modified electrode significantly enhanced the oxidation peak current and lowered the oxidation overpotential to improve the sensitivity. Several important parameters which can influence the performance of the sensor were studied and optimized. The sensor showed a fast and sensitive response for the quantitative determination of BPA under optimum conditions. It exhibited a good linear relationship range from 5.0 nmol L−1 to 20 μmol L−1 and the detection limit was 1.7 nmol L−1, (S/N = 3). The sensor exhibited remarkable sensitivity (3.830 μA (μmol L−1)−1). Furthermore, the fabricated sensor showed an excellent result for the detection of BPA in milk samples.
